Module 1: The Clotting Cascade
In this module, we’ll explore what happens when bleeding is caused by an injury and how a process called hemostasis occurs at the site of the injury to form a clot and stop the bleed, including a crucial part of hemostasis - The Clotting Cascade!
Learn more by checking out the Clotting Cascade infographic from The Science Fair:
Module 2: Factor 8 and Friends
The story of factor 8 (VIII) begins in the liver. Factor 8 (VIII) is a protein and it is made in the liver. Do you know what factor 8 (VIII)’s job is? The job of factor 8 (VIIII) is to connect factor 9 (IX) and factor 10 (X), so that when they are together, they help create a blood clot. In this module, you get to connect factor 8 (VIII) and factor 9 (IX) with Factor 10 (X) to help form the clot!
Learn more by checking out the Factor 8 & Friends infographic from The Science Fair:
Module 3: All About vWD
We learned that von Willebrand factor (vWF) plays a crucial role in achieving hemostasis, so what if VFW is missing or deficient? von Willebrand factor (vWF) has two jobs - To recruit platelets to the site of a blood vessel tear and to act as a chaperone for Factor 8 (VIII).
Learn more by checking out the von Willebrand Disease infographic from The Science Fair:
Module 4: The “B” Exceptional Experience
We just learned that factor 8 (VIII) joins with factor 9 (IX) to activate factor 10a (X), a crucial component of the intrinsic pathway during the clotting process. Did you know there are differences between factor 8 (VIII) and factor 9 (IX)? Those differences may impact how factor 9 (IX) deficiency is managed. In this module we test your factor 9 (IV) and factor 8 (VIII) knowledge!
Learn more by checking out the hemophilia B infographic from The Science Fair:
Module 5: We Care About Rare
The Clotting Cascade isn’t affected by just factor 8 (VIII) and Factor 9 (IX) deficiencies. Other clotting factors can be deficient leading to rare bleeding disorders. In the US, a rare disease or disorder is defined as one that affects fewer than 200,000 people, making hemophilia A and B, and still less prevalent factor deficiencies such as 1, 2, 5, 7, 10, 11, 12 and 13, rare disorders.
Module 6: When Bleeds Happen
Ever wonder what actually happens when a bleed occurs? Let’s find out! As you learned in module one, if someone doesn’t have enough factor 8 to connect factor 9 and 10, then a blood clot is unable to form and bleeding episodes go on and on… So let’s see what happens inside a knee when a bleed happens!
Learn more by checking out the When Bleeds Happen infographic from The Science Fair:
Module 7: A Microscopic Look at How We Treat Hemophilia
Each microscope has six petri dishes that tell a different story about the history of hemophilia treatment. Make sure to start with petri dish #1 to get the full story of how science evolved!
Module 8: Women Bleed Too
While it’s estimated that as many as 1.6 million American women may have a bleeding disorder, according to ATHN dataset, fewer than 8,000 have been diagnosed (0.5%). We take a deep dive into facts about women and bleeding disorders in this module.
Learn more by checking out the Women With Bleeding Disorders infographic from The Science Fair:
Module 9: The Future is Under Construction
You just saw how we treat hemophilia but did you know the future is under construction? Let’s learn more about investigational gene therapy science!
Learn more by checking out the Treatment Options of Tomorrow infographic from The Science Fair: